Prodrugs and Targeted Delivery - copertina rigida, flessible

EAN (ISBN-13): 9783527326037
ISBN (ISBN-10): 3527326030
Copertina rigida
Anno di pubblicazione: 2010
Editore: Rautio, Jarkko, Wiley-VCH
496 Pagine
Peso: 1,104 kg
Lingua: eng/Englisch

Libro nella banca dati dal 2007-01-16T12:28:29+01:00 (Zurich)
Pagina di dettaglio ultima modifica in 2023-09-23T10:37:34+02:00 (Zurich)
ISBN/EAN: 3527326030

ISBN - Stili di scrittura alternativi:
3-527-32603-0, 978-3-527-32603-7
Stili di scrittura alternativi e concetti di ricerca simili:
Autore del libro : kubinyi, rauti, raimund, hugo, wiley vch, gerd folkers
Titolo del libro: delivery beyond, principles chemistry

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Dati dell'editore

Autore: Jarkko Rautio
Titolo: Methods and Principles in Medicinal Chemistry; Prodrugs and Targeted Delivery - Towards Better ADME Properties
Editore: Wiley-VCH; Wiley-VCH
496 Pagine
Anno di pubblicazione: 2010-12-15
Stampato / Fatto in
Peso: 1,432 kg
Lingua: Inglese
185,00 € (DE)
190,20 € (AT)
Available
170mm x 240mm x 39mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Medizin, Gesundheit; Arzneimittelentwicklung; Arzneimittelforschung; Chemie; Chemistry; Drug Discovery & Development; Drug Formulation & Delivery; Toxicology; Toxikologie; Wirkstoff; Wirkstoffformulierung, Wirkstofftransport; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Wirkstoffformulierung, Wirkstofftransport; Toxikologie

By definition, drugs are highly active substances that are beneficial if they act at the right time and in the right place, but can cause harm otherwise. A clever strategy to ensure that a drug only becomes active when needed is to "camouflage" it. Such camouflaged, i.e. deactivated, drugs that become chemically or biochemically activated once they reach their site of action are called prodrugs. This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies, beginning at the early stages of the development process, while also discussing organ- and site-selective prodrugs. From the contents: * Prodrug design and intellectual property * Prodrugs addressing ADMET issues * Codrugs and soft drugs * Preclinical and clinical consideration for prodrugs This book is a valuable reference for all companies employing medicinal chemists by giving a practice-oriented overview of a key strategy in modern drug discovery and development.