2012, ISBN: 3527330852
[EAN: 9783527330850], Neubuch, [PU: Wiley-VCH GmbH], CHEMIE MEDIZIN BASIC PHARMACOLOGY CHEMISTRY DRUG DISCOVERY & DEVELOPMENT GRUNDLAGEN DER PHARMAKOLOGIE MEDICAL SCIENCE TOXICOLOGY TOXIK… Altro …
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Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - copertina rigida, flessible
2012, ISBN: 9783527330850
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Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - copertina rigida, flessible
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2012, ISBN: 3527330852
[EAN: 9783527330850], Neubuch, [PU: Wiley-VCH GmbH], CHEMIE MEDIZIN BASIC PHARMACOLOGY CHEMISTRY DRUG DISCOVERY & DEVELOPMENT GRUNDLAGEN DER PHARMAKOLOGIE MEDICAL SCIENCE TOXICOLOGY TOXIK… Altro …
Kalgutkar, Amit S.; Dalvie, Deepak; Obach, R. Scott; Smith, Douglas A.; Mannhold, Raimund [Series Editor]; Kubinyi, Hugo [Series Editor]; Folkers, Gerd [Series Editor];:
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - copertina rigida, flessible2012, ISBN: 9783527330850
Wiley-VCH, 2012-12-26. Hardcover. Used:Good., Wiley-VCH, 2012-12-26, 0
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - copertina rigida, flessible
2012
ISBN: 9783527330850
Wiley-VCH, 2012-12-26. 1. Hardcover. Good., Wiley-VCH, 2012-12-26, 2.5
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - copertina rigida, flessible
2012, ISBN: 3527330852
[EAN: 9783527330850], Neubuch, [PU: Wiley VCH 2012-10-24]
2012, ISBN: 9783527330850
edizione con copertina rigida
Buch, Hardcover, 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012
Dati bibliografici del miglior libro corrispondente
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pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.
The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive
and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating
the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.
Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Informazioni dettagliate del libro - Reactive Drug Metabolites
EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Copertina rigida
Anno di pubblicazione: 2012
Editore: Wiley-VCH
386 Pagine
Peso: 1,017 kg
Lingua: Englisch
Libro nella banca dati dal 2007-04-28T00:39:27+02:00 (Zurich)
Pagina di dettaglio ultima modifica in 2023-04-05T14:49:48+02:00 (Zurich)
ISBN/EAN: 3527330852
ISBN - Stili di scrittura alternativi:
3-527-33085-2, 978-3-527-33085-0
Stili di scrittura alternativi e concetti di ricerca simili:
Autore del libro : scott, deepak, amit, douglas smith, dennis, raimund, hugo kubinyi, gerd folkers, kalg
Titolo del libro: amit
Dati dell'editore
Autore: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Titolo: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Editore: Wiley-VCH; Wiley-VCH
386 Pagine
Anno di pubblicazione: 2012-10-24
Stampato / Fatto in
Peso: 1,000 kg
Lingua: Inglese
172,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 25mm
BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Chemie; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.Altri libri che potrebbero essere simili a questo:
Ultimo libro simile:
9783527655762 Reactive Drug Metabolites (Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith)
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