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P53 - Springer
libro esaurito
(*)
Springer:
P53 - nuovo libro

2010, ISBN: 9781441982308

ID: 664245863

Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research. Presenting key ideas in the field, this volume explores how transgenics have been used to study p53. The text explores how clinical genetics have identified and mutations in p53 found in human cancers, and how p53 can be regulated by post-translational modification. Bücher > Fremdsprachige Bücher > Englische Bücher gebundene Ausgabe 16.12.2010 Buch (fremdspr.), Springer, .201

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P53 - Springer
libro esaurito
(*)
Springer:
P53 - nuovo libro

ISBN: 9781441982308

ID: 4a889baf3ce08e5ece5f483e02841441

Presenting key ideas in the field, this volume explores how transgenics have been used to study p53. The text explores how clinical genetics have identified and mutations in p53 found in human cancers, and how p53 can be regulated by post-translational modification. Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research. Bücher / Fremdsprachige Bücher / Englische Bücher 978-1-4419-8230-8, Springer

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P53 - Springer
libro esaurito
(*)
Springer:
P53 - nuovo libro

ISBN: 9781441982308

ID: 664450461

Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research. Presenting key ideas in the field, this volume explores how transgenics have been used to study p53. The text explores how clinical genetics have identified and mutations in p53 found in human cancers, and how p53 can be regulated by post-translational modification. Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Springer

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P53 - Ayeda Ayed
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Ayeda Ayed:
P53 - nuovo libro

1, ISBN: 9781441982308

[ED: Buch], [PU: SPRINGER VERLAG GMBH], Neuware - Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 236x161x18 mm, 200, [GW: 419g], PayPal, Banküberweisung, Internationaler Versand

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P53 - Ayed, Ayeda, Ph.D. (EDT)/ Hupp, Theodore, Ph.D. (EDT)
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Ayed, Ayeda, Ph.D. (EDT)/ Hupp, Theodore, Ph.D. (EDT):
P53 - copertina rigida, flessible

ISBN: 9781441982308

ID: 9781441982308

hardback, [PU: Springer]

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Blackwells.co.uk
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p53
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This volume, p53, was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical genetics have identified and studied mutations in p53 found in human cancers, how p53 can be regulated by post-translational modification, and how key drug targets have been defined, namely MDM2, which has provided fundamental approaches for defining how p53 can be activated with potentially therapeutic effect. The key concepts in the chapters included provide a perspective on key paradigms in the p53 field.

Informazioni dettagliate del libro - p53


EAN (ISBN-13): 9781441982308
ISBN (ISBN-10): 1441982302
Copertina rigida
Anno di pubblicazione: 2011
Editore: Springer-Verlag GmbH
200 Pagine
Peso: 0,419 kg
Lingua: eng/Englisch

Libro nella banca dati dal 20.01.2008 04:17:28
libro trovato per l'ultima volta il25.05.2018 13:20:34
ISBN/EAN: 9781441982308

ISBN - Stili di scrittura alternativi:
1-4419-8230-2, 978-1-4419-8230-8


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