2007, ISBN: 9783843390064

Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally si… Altro …

Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally silences one X- chromosome in every female cell. The choice of which X-chromosome should be turned-off is considered to be random. Studies on mice have revealed that a locus on the X-chromosome, the X controlling element (Xce), significantly influences the choice of which X- chromosome is inactivated. Renault et al. (2007) studied a family of which many of the females exhibit symptoms of the X-linked recessive disease, Haemophilia A. The XCI ratios of the women in this family were significantly different from what would be expected if the XCI process was random. This studies result is consistent with the human XCE hypothesis. Random and genetic models of XCI ratios are investigated here in theory and are compared to a sample of XCI ratios. Using goodness-of- fit testing, it is determined which models best fit the data. Anderson-Darling statistics and visual inspection of graphics suggest that a three allele genetic model is a good fit to the data, supporting the human XCE hypothesis. New Textbooks>Trade Paperback>Science>Statistics & Probability>Statistics & Probability, LAP Lambert Academic Publishing Core >1 >T<

2011, ISBN: 9783843390064

Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally si… Altro …

Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally silences one X- chromosome in every female cell. The choice of which X-chromosome should be 'turned-o¿' is considered to be random. Studies on mice have revealed that a locus on the X-chromosome, the X controlling element (Xce), signi¿cantly in¿uences the choice of which X- chromosome is inactivated. Renault et al. (2007) studied a family of which many of the females exhibit symptoms of the X-linked recessive disease, Haemophilia A. The XCI ratios of the women in this family were signi¿cantly di¿erent from what would be expected if the XCI process was random. This studies result is consistent with the human XCE hypothesis. Random and genetic models of XCI ratios are investigated here in theory and are compared to a sample of XCI ratios. Using goodness-of- fit testing, it is determined which models best fit the data. Anderson-Darling statistics and visual inspection of graphics suggest that a three allele genetic model is a good fit to the data, supporting the human XCE hypothesis. Buch (fremdspr.) Sonja Pritchett Taschenbuch, LAP LAMBERT Academic Publishing, 31.01.2011, LAP LAMBERT Academic Publishing, 2011<

2011, ISBN: 9783843390064

Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally si… Altro …

Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally silences one X- chromosome in every female cell. The choice of which X-chromosome should be 'turned-o¿' is considered to be random. Studies on mice have revealed that a locus on the X-chromosome, the X controlling element (Xce), signi¿cantly in¿uences the choice of which X- chromosome is inactivated. Renault et al. (2007) studied a family of which many of the females exhibit symptoms of the X-linked recessive disease, Haemophilia A. The XCI ratios of the women in this family were signi¿cantly di¿erent from what would be expected if the XCI process was random. This studies result is consistent with the human XCE hypothesis. Random and genetic models of XCI ratios are investigated here in theory and are compared to a sample of XCI ratios. Using goodness-of- fit testing, it is determined which models best fit the data. Anderson-Darling statistics and visual inspection of graphics suggest that a three allele genetic model is a good fit to the data, supporting the human XCE hypothesis. Buch (fremdspr.) Sonja Pritchett Taschenbuch, LAP LAMBERT Academic Publishing, 31.01.2011, LAP LAMBERT Academic Publishing, 2011<

2011, ISBN: 3843390061

[EAN: 9783843390064], Neubuch, [PU: LAP LAMBERT Academic Publishing], MATHEMATIK WAHRSCHEINLICHKEITSTHEORIE STOCHASTIK MATHEMATISCHE STATISTIK ANDERSON-DARLING GENETICS X-CHROMOSOME INACT… Altro …

[EAN: 9783843390064], Neubuch, [PU: LAP LAMBERT Academic Publishing], MATHEMATIK WAHRSCHEINLICHKEITSTHEORIE STOCHASTIK MATHEMATISCHE STATISTIK ANDERSON-DARLING GENETICS X-CHROMOSOME INACTIVATION MIXTURE MODELS GOODNESS-OF-FIT, Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Pritchett SonjaSonja Pritchett graduated with highest aggregate from Mount Saint Vincent University in Halifax, NS, in May 2006 with a BSc, major in Mathematics. In May 2009, Sonja graduated with a Masters in Statistics from Dalhousi., Books<

2011, ISBN: 3843390061

Kartoniert / Broschiert, mit Schutzumschlag 11, [PU:LAP LAMBERT Academic Publishing]