2017, ISBN: 1493969536

Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and can… Altro …

Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and cancer predisposition. This detailed volume explores the ever expanding field of research into the ATM (ataxia-telangiectasia, mutated) gene and the role played by ATM kinase in DNA damage signaling and diverse cellular processes. What follows is a handy desktop reference for both seasoned A-T researchers and postgraduate students, as it demonstrates the breadth of recent developments in A-T studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Both classic and cutting-edge techniques are described, including ATM gene mutation detection, assays for radiosensitivity and radioresistant DNA synthesis, new methods to measure ATM kinase activity by imaging microscopy and high content screening as well as proteomics, phosphoproteomics and bioinformatics approaches to decipher ATM-dependent signalling pathways. Additional methods include generation of patient-specific stem cells and approaches to study ATM functions in the nervous system. Comprehensive and practical, ATM Kinase: Methods and Protocols aims to ignite and attract the interest of colleagues from diverse fields to A-T research in an effort to bring their expertise and fresh ideas to resolve many A-T puzzles still waiting to be pieced together and to alleviate the suffering of A-T children and their families. Media Buch, 437 Seiten, Media > Books, National Institutes of Health, 2017<

ISBN: 9781493969531

Hardback, [PU: Humana Press Inc.], Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodeg… Altro …

Hardback, [PU: Humana Press Inc.], Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and cancer predisposition. This detailed volume explores the ever expanding field of research into the ATM (ataxia-telangiectasia, mutated) gene and the role played by ATM kinase in DNA damage signaling and diverse cellular processes. What follows is a handy desktop reference for both seasoned A-T researchers and postgraduate students, as it demonstrates the breadth of recent developments in A-T studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Both classic and cutting-edge techniques are described, including ATM gene mutation detection, assays for radiosensitivity and radioresistant DNA synthesis, new methods to measure ATM kinase activity by imaging microscopy and high content screening as well as proteomics, phosphoproteomics and bioinformatics approaches to decipher ATM-dependent signalling pathways. Additional methods include generation of patient-specific stem cells and approaches to study ATM functions in the nervous system. Comprehensive and practical, ATM Kinase: Methods and Protocols aims to ignite and attract the interest of colleagues from diverse fields to A-T research in an effort to bring their expertise and fresh ideas to resolve many A-T puzzles still waiting to be pieced together and to alleviate the suffering of A-T children and their families., Medical Genetics<

ISBN: 9781493969531

Ataxia–telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and can… Altro …

Ataxia–telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and cancer predisposition. This detailed volume explores the ever expanding field of research into the ATM (ataxia-telangiectasia, mutated) gene and the role played by ATM kinase in DNA damage signaling and diverse cellular processes. What follows is a handy desktop reference for both seasoned A-T researchers and postgraduate students, as it demonstrates the breadth of recent developments in A-T studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Both classic and cutting-edge techniques are described, including ATM gene mutation detection, assays for radiosensitivity and radioresistant DNA synthesis, new methods to measure ATM kinase activity by imaging microscopy and high content screening as well as proteomics, phosphoproteomics and bioinformatics approaches to decipher ATM-dependent signalling pathways. Additional methods include generation of patient-specific stem cells and approaches to study ATM functions in the nervous system. Comprehensive and practical, ATM Kinase: Methods and Protocols aims to ignite and attract the interest of colleagues from diverse fields to A-T research in an effort to bring their expertise and fresh ideas to resolve many A-T puzzles still waiting to be pieced together and to alleviate the suffering of A-T children and their families., Humana<

2017, ISBN: 1493969536

Gebundene Ausgabe Forschung (medizinisch, psychologisch), Genetik / Humangenetik, Humangenetik, Heilkunde, Humanmedizin, Medizin, Medizin / Spezialgebiete, Biologie / Molekularbiologie, … Altro …

Gebundene Ausgabe Forschung (medizinisch, psychologisch), Genetik / Humangenetik, Humangenetik, Heilkunde, Humanmedizin, Medizin, Medizin / Spezialgebiete, Biologie / Molekularbiologie, Molekularbiologie, Biologie / Zellbiologie, Zellbiologie, Zelle (biologisch) / Zellbiologie, Cytologie, Zelle (biologisch) / Zytologie, Zytologie, Innere Medizin, Medizin / Innere Medizin, Anatomie (des Menschen), Mensch / Anatomie, MEDICAL / Genetics, Genetik, Medizin, Medizinische Spezialgebiete, Zellbiologie (Zytologie), Klinische und Innere Medizin, Ataxia-telangiectasia (A-T); Genetic disorder; DNA damage; Mutated; ATM gene, Protège-cahier 11, [PU:Springer-Verlag GmbH; Springer US]<

2017, ISBN: 1493969536

1st ed. 2017 Gebundene Ausgabe Genetik / Humangenetik, Humangenetik, Ataxia¿telangiectasia(A-T); Geneticdisorder; DNAdamage; mutated; ATMgene, mit Schutzumschlag 11, [PU:Springer New Yo… Altro …

1st ed. 2017 Gebundene Ausgabe Genetik / Humangenetik, Humangenetik, Ataxia¿telangiectasia(A-T); Geneticdisorder; DNAdamage; mutated; ATMgene, mit Schutzumschlag 11, [PU:Springer New York; Springer US]<